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KMID : 0361020020450100975
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Korean Journal of Otolaryngology - Head and Neck Surgery
2002 Volume.45 No. 10 p.975 ~ p.979
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The Effect of Hemodialysis on the Olfactory Function in Chronic Renal Failure Patients
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김진국/Jin Kook Kim
임채형/남태욱/조영일/신석균/Chae Hyoung Lim/Tae Wook Nam/Young Il Jo/Sug Kyun Shin
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Abstract
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Background and Objectives: The sense of smell plays an important role in the quality of life. Loss of smell is common in the elderly and it results from respiratory diseases, certain disease states (Alzheimer disease, chronic renal failure
(CRF),
multiple sclerosis), medications, and surgical interventions. Many studies have shown a declining odor perception in the CRF patients. The objectives of the present study were to test odor identification ability in patients with CRF and the effect
of
hemodialysis on olfactory recognition, and to examine the possible correlations between smell identification test score and various clinical parameters.
Materials and Method: We performed a case-control study comparing the Cross- Cultural Smell Identification Test (CC-SIT) scores of CRF patients with hemodialysis, and those without hemodialysis, and age-sex matched healthy controls.
Results:Healthy controls had significantly high CC-SIT scores compared to those of CRF patients without hemodialysis. No significant differences were observed in the CC-SIT scores between CRF patients with hemodialysis and healthy controls
and
in CRF patients before and after the hemodialysis session. No significant positive correlation was found between CC-SIT score and creatinine clearance in the dialysis group.
Conclusion: Acute removal of uremic toxins by hemodialysis does not correct olfactory disturbances. Odor perception is severly impaired in patients with CRF and is related to the degree of renal impairment.
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KEYWORD
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